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Cancer and Ageing Research Group

Research in the Cancer and Ageing Research Group follows a multi-disciplinary and highly collaborative approach to increase understanding of disease characteristically associated with ageing at the molecular level, to improve prevention, diagnosis, and treatment.

The group has developed strong collaborative links with scientists at the Schools of Pharmacy, Chemistry, Mathematics and Physics, Computer Sciences, the Lincoln Institute for Health and College of Social Science.

Work is supported by the BBSRC, Celgene Limited, Boston & District Fundraising Group Leukaemia & Lymphoma Research – Boston Branch, and Shires Pharmaceutical Development Ltd.

Research is based on in vitro modelling and we extensively use tissue culture, microscopy (including laser scanning confocal microscopy, live cell imaging, atomic force microscopy and scanning electron microscopy), Flow cytometry, traditional and advanced molecular biology techniques, yeast models and bioinformatics.

The strength of the group is in unity cemented together by the common interest in ageing related biomedical research including cancer (Csanad Bachrati, Issam Hussain, Stefan Millson Timea PalmaiPallag, Prof Ciro Rinaldi), neurodegenerative diseases (Humberto Gutierrez, Yvonne Nyathi),  stroke and cardiovascular diseases (Steve Bevan, Prof Carlos Rodriguez Pascual), arthritis (Csanad Bachrati), pulmonary fibrosis (Yvonne Nyathy), geriatric medicine, frailty and geriatric assessment (Prof  Carlos Rodriguez Pascual). Our current research projects include:

Cancer Research

  • Gene expression changes associated with essential thrombocythema and myelodysplastic syndromes and their implication in therapy (Prof Ciro Rinaldi)
  • Elucidating the molecular mechanisms in myelodysplastic syndromes and myeloproliferative neoplasms (Ciro Rinaldi)
  • Elucidating the cellular function of DNA topoisomerase III alpha (Csanad Bachrati)
  • Characterising novel proteins potentially involved in homologous recombination (Csanad Bachrati)
  • Establishing a cellular model for the development of osteosarcoma (Csanad Bachrati)
  • Molecular chaperons in proteomics of interactions (Stefan Millson)
  • Targeting the heatshock response in cancer therapy (Stefan Millson)
  • Exosome-delivered regulators in the formation of distant metastatic niches (Timea Palmai-Pallag)
  • Development of synthetic receptor ligands with anti-tumour and anti-seizure properties (Issam Hussain)

Neurodegenerative diseases

  • Identifying genomic and molecular determinants of neuronal survival (Humberto Gutierrez)
  • Detection of wider gene networks involved in post-mitotic cell maintenance in a mouse model of accelerated brain ageing (Humberto Gutierrez)
  • Detection of wider gene networks involved in post-mitotic cell maintenance in a mouse model of accelerated brain ageing (Humberto Gutierrez)

Stroke and cardiovascular diseases

  • Low-frequency and common genetic variation in ischemic stroke (Steve Bevan)
  • Contribution of subclinical cardiovascular disease to physical and cognitive frailty syndrome (Prof Carlos Rodriguez Pascual)
  • Efficiency of physical frailty markers to determine the prognosis of advanced age patients with severe aortic stenosis and heart failure (Prof Carlos Rodriguez Pascual)
  • Efficiency of a disease management program in very elderly patients with heart failure and high comorbidity (Prof Carlos Rodriguez Pascual)

Palmai-Pallag, Timea and Bachrati, Csanad (2014) Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle. Microbes and Infection, 16 (10). pp. 822-832. ISSN: 1286-4579

Pfister, Sophia X. and Ahrabi, Sara and Zalmas, Lykourgos-Panagiotis and Sarkar, Sovan and Aymard, François and Bachrati, Csanad and Helleday, Thomas and Legube, Gaëlle and LaThangue, Nicholas B. and Porter, Angrew C. G. and Humphrey, Timothy C. (2014) SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Reports, 7 (6). pp. 2006-2018. ISSN: 2211-1247

Clynes, David and Jelinska, Clare and Xella, Barbara and Ayyub, Helena and Taylor, Stephen and Mitson, Matthew and Bachrati, Csanad Z. and Higgs, Douglas R. and Gibbons, Richard J. (2014) ATRX dysfunction Induces replication defects in primary mouse cells. PLoS ONE, 9 (3). pp. e92915. ISSN: 1932-6203

Klaus, K. and Butler, K. and Durrant, S. J. and Ali, M. and Inglehearn, C. F. and Hodgson, T. L. and Gutierrez, H. and Pennington, K. (2017) The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress. Brain and Behavior, e00695. ISSN: 2162-3279

Collins, Louise M. and Dal Bo, Giorgia and Calcagno, Mariangela and Monzón-Sandoval, Jimena and Sullivan, Aideen M. and Gutierrez, Humberto and Morari, Michele and O’Keeffe, Gerard W. (2016) Nociceptin/orphanin FQ inhibits the survival and axon growth of midbrain dopaminergic neurons through a p38-MAPK dependent mechanism. Molecular Neurobiology, 53 (10). pp. 7284-7297. ISSN: 0893-7648

Monzón-Sandoval, Jimena and Castillo-Morales, Atahualpa and Urrutia, Araxi O. and Gutierrez, Humberto (2016) Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development.. BMC developmental biology, 16. pp. 13. ISSN: 1471-213X

O’Keeffe, Gerard W. and Gutierrez, Humberto and Howard, Laura and Laurie, Christopher W. and Osorio, Catarina and Gavaldà, Núria and Wyatt, Sean L. and Davies, Alun M. (2016) Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation. Neural Development, 11 (1). ISSN: 1749-8104

Monzón-Sandoval, Jimena and Castillo-Morales, Atahualpa and Crampton, Sean and McKelvey, Laura and Nolan, Aoife and O’Keeffe, Gerard and Gutierrez, Humberto (2015) Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system. Frontiers in Cellular Neuroscience, 9. ISSN: 1662-5102

Sheikh, Ahmad Hassan and Barry, Denis S, and Gutierrez, Humberto and Cryan, John F. and O'Keeffe, Gerard W. (2015) Cadaveric anatomy in the future of medical education: what is the surgeons view?. Anatomical Sciences Education, 9 (2). pp. 203-208. ISSN: 1935-9772

Nolan, Aoife M. and Collins, Louise M. and Wyatt, Sean L. and Gutierrez, Humberto and O'Keeffe, Gerard W. (2014) The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age. Differentiation, 88 (4-5). pp. 124-130. ISSN: 0301-4681

Togher, K. L. and O'Keeffe, M. M. and Khashan, A. S. and Gutierrez, Humberto and Kenny, L. C. and O'Keeffe, G. W. (2014) Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal development. Epigenetics, 9 (6). pp. 816-822. ISSN: 1559-2294

Coceano, G. and Yousafzai, M. S. and Ma, W. and Ndoye, F. and Venturelli, L. and Hussain, I. and Bonin, S. and Niemela, J. and Scoles, G. and Cojoc, D. and Ferrari, E. (2016) Investigation into local cell mechanics by atomic force microscopy mapping and optical tweezer vertical indentation. Nanotechnology, 27 (6). pp. 65102. ISSN: 0957-4484

Arif, Khalid and Hussain, Issam and Rea, Carol and El-Sheemy, Mohamed (2015) The role of Nanog expression in tamoxifen-resistant breast cancer cells. OncoTargets and Therapy, 8. pp. 1327-1334. ISSN: 1178-6930

Alghamdi, Ibrahim and Hussain, Issam and Alghamdi, Mohamed and Dohal, Ahlam and El-Sheemy, Mohamed (2015) The incidence rate of thyroid cancer among women in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001–2008. Journal of Immigrant and Minority Health, 17 (3). pp. 638-643. ISSN: 1557-1912

Alghamdi, Ibrahim and Hussain, Issam and Alghamdi, Mohamed and El-Sheemy, Mohamed (2015) The power of the age standardized incidence rate to discover the gene link between cancer diseases: development of a new epidemiological method to save money, time, and effort for genetic scientists. OncoTargets and Therapy, 8. pp. 677. ISSN: 1178-6930,

Chan, C. W. and Hussain, Issam and Waugh, David and Lawrence, Jonathan and Man, H. C. (2014) Effect of laser treatment on the attachment and viability of mesenchymal stem cell responses on shape memory NiTi alloy. Materials Science and Engineering C, 42. pp. 254-263. ISSN: 0928-4931

Alghamdi, Ibrahim and Hussain, Issam and Almalki, Shaia and Alghamdi, Mohamed and Alghamdi, Mansour and El-Sheemy, Mohammed (2014) The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health. International Journal of General Medicine, 7. pp. 417-423. ISSN: 1178-7074

Alghamdi, I. G. and Hussain, I. I. and Alghamdi, M. S. and Dohal, A. A. and El-Sheemy, M. A. (2014) The incidence of leukemia in Saudi Arabia: descriptive epidemiological analysis of data from the Saudi cancer registry (2001-2008). Saudi Medical Journal, 35 (7). pp. 674-683. ISSN: 0379-5284

Alghamdi, I G. and Hussain, I. I. and Alghamdi, M. S. and Dohal, A. A. and Alghamdi, M. M. and El-Sheemy, M. A. (2014) Incidence rate of non-Hodgkin's lymphomas among males in Saudi Arabia: an observational descriptive epidemiological analysis of data from the Saudi cancer registry, 2001-2008. International Journal of General Medicine, 7. pp. 311-317. ISSN: 1178-7074

Alghamdi, Ibrahim and Hussain, Issam and Alghamdi, Mohamed and Alghamdi, Mansour and Dohal, Ahlam and El-Sheemy, Mohammed (2014) Incidence rate of ovarian cancer cases in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001–2008. Int J Womens Health, 6 (1). pp. 639-645. ISSN: 1179-1411

Alghamidi, Ibrahim G. and Hussain, Issam I. and Alghamdi, Mohamed S. and El-Sheemy, Mohammed A. (2014) The incidence rate of prostate cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from the Saudi Cancer Registry 2001–2008. Hematology/Oncology and Stem Cell Therapy, 7 (1). pp. 18-26. ISSN: 1658-3876

Alghamdi, Ibrahi. and Hussain, Issam and El-Sheemy, Mohamed and Alghamdi, Mohammed (2013) The incidence rate of female breast cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Breast Cancer: Targets and Therapy, 2013 (5). pp. 103. ISSN: 1179-1314

Willhoft, Oliver and Kerr, Richard and Patel, Dipali and Zhang, Wenjuan and Al-Jassar, Caezar and Daviter, Tina and Millson, Stefan H. and Thalassinos, Konstantinos and Vaughan, Cara K. (2017) The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores. Scientific Reports, 7. pp. 41626. ISSN: 2045-2322

Gomez-Escalante, Susana and Piper, Peter W. and Millson, Stefan H. (2017) Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival. Cell Stress and Chaperones, 22 (1). pp. 135-141. ISSN: 1355-8145

Millson, Stefan and van Oosten-Hawle, Patricija and Alkuriji, Mohammed A. and Truman, Andrew and Siderius, Marco and Piper, Peter W. (2014) Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1). Cell Stress and Chaperones, 19 (5). pp. 695-703. ISSN: 1355-8145

Millson, S. H. and Piper, P. W. (2014) Insights from yeast into whether the inhibition of heat shock transcription factor (Hsf1) by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor. Oncotarget, 5 (13). pp. 5054-5064. ISSN: 1949-2553

Caponnetto, Federica and Manini, Ivana and Skrap, Miran and Palmai-Pallag, Timea and Di Loreto, Carla and Beltrami, Antonio Paolo and Cesselli, Daniela and Ferrari, Enrico (2017) Size-dependent cellular uptake of exosomes. Nanomedicine: Nanotechnology, Biology and Medicine, 13 (3). ISSN: 1549-9634

Nielsen, Christian F. and Huttner, Diana and Bizard, Anna H. and Hirano, Seiki and Li, Tian-Neng and Palmai-Pallag, Timea and Bjerregaard, Victoria A. and Liu, Ying and Nigg, Erich A. and Wang, Lily Hui-Ching and Hickson, Ian D. (2015) PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis. Nature Communications, 6. pp. 8962. ISSN: 2041-1723

Herr, Patrick and Lundin, Cecilia and Evers, Bastiaan and Ebner, Daniel and Bauerschmidt, Christina and Kingham, Guy and Palmai-Pallag, Timea and Mortusewicz, Oliver and Frings, Oliver and Sonnhammer, Erik and Helleday, Thomas (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery. pp. 15034. ISSN: 2056-5968

Xing, Meichun and Wang, Xiaohui and Palmai-Pallag, Timea and Shen, Huahao and Helleday, Thomas and Hickson, Ian D. and Ying, Songmin (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646. ISSN: 1949-2553

Cai, Zhiwei and Palmai-Pallag, Timea and Khuituan, Pissared and Mutolo, Michael J and Boinot, Clément and Liu, Beihui and Scott-Ward, Toby S and Callebaut, Isabelle and Harris, Ann and Sheppard, David N (2015) Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating. Journal of Physiology, 593 (11). pp. 2427-2446. ISSN: 0022-3751

Cao, Chao and Gu, Yangjun and Zhu, Chen and Palmai-Pallag, Timea and Lan, Fen and Chen, Zhihua and Li, Wen and Shen, Huahao and Ying, Songmin (2014) Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology. Recent Patents on Anti-Cancer Drug Discovery, 9 (2). pp. 241-248. ISSN: 1574-8928

Mesa R, Vannucchi AM, Yacoub A, Zachee P, Garg M, Lyons R, Koschmieder S, Rinaldi C, Byrne J, Hasan Y, Passamonti F, Verstovsek S, Hunter D, Jones MM, Zhen H, Habr D, Martino B. (2016) The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double-blind, double-dummy, symptom study (RELIEF). Br J Haematol. 2017 Jan;176(1):76-85. doi: 10.1111/bjh.14382. Epub 2016 Nov 8.

Prins, Bram P. and Abbasi, Ali and Wong, Anson and Vaez, Ahmad and Nolte, Ilja and Franceschini, Nora and Stuart, Philip E. and Guterriez Achury, Javier and Mistry, Vanisha and Bradfield, Jonathan P. and Valdes, Ana M. and Bras, Jose and Shatunov, Aleksey and Lu, Chen and Han, Buhm and Raychaudhuri, Soumya and Bevan, Steve and Mayes, Maureen D. and Tsoi, Lam C. and Evangelou, Evangelos and Nair, Rajan P. and Grant, Struan F. A. and Polychronakos, Constantin and Radstake, Timothy R. D. and van Heel, David A. and Dunstan, Melanie L. and Wood, Nicholas W. and Al-Chalabi, Ammar and Dehghan, Abbas and Hakonarson, Hakon and Markus, Hugh S. and Elder, James T. and Knight, Jo and Arking, Dan E. and Spector, Timothy D. and Koeleman, Bobby P. C. and van Duijn, Cornelia M. and Martin, Javier and Morris, Andrew P. and Weersma, Rinse K. and Wijmenga, Cisca and Munroe, Patricia B. and Perry, John R. B. and Pouget, Jennie G. and Jamshidi, Yalda and Snieder, Harold and Alizadeh, Behrooz Z. (2016) Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study. PLoS medicine, 13 (6). pp. e1001976. ISSN: 1549-1277

Traylor, Matthew and Rutten-Jacobs, Loes C. A. and Thijs, Vincent and Holliday, Elizabeth G. and Levi, Chris and Bevan, Steve and Malik, Rainer and Boncoraglio, Giorgio and Sudlow, Cathie and Rothwell, Peter M. and Dichgans, Martin and Markus, Hugh S. (2016) Genetic associations with white matter hyperintensities confer risk of lacunar stroke. Stroke: a Journal of Cerebral Circulation, 47 (5). pp. 1174-9. ISSN: 0039-2499

Malik, Rainer and Traylor, Matthew and Pulit, Sara L. and Bevan, Steve and Hopewell, Jemma C. and Holliday, Elizabeth G. and Zhao, Wei and Abrantes, Patricia and Amouyel, Philippe and Attia, John R. and Battey, Thomas W. K. and Berger, Klaus and Boncoraglio, Giorgio B. and Chauhan, Ganesh and Cheng, Yu-Ching and Chen, Wei-Min and Clarke, Robert and Cotlarciuc, Ioana and Debette, Stephanie and Falcone, Guido J. and Ferro, Jose M. and Gamble, Dale M. and Ilinca, Andreea and Kittner, Steven J. and Kourkoulis, Christina E. and Lemmens, Robin and Levi, Christopher R. and Lichtner, Peter and Lindgren, Arne and Liu, Jingmin and Meschia, James F. and Mitchell, Braxton D. and Oliveira, Sofia A. and Pera, Joana and Reiner, Alex P. and Rothwell, Peter M. and Sharma, Pankaj and Slowik, Agnieszka and Sudlow, Cathie L. M. and Tatlisumak, Turgut and Thijs, Vincent and Vicente, Astrid M. and Woo, Daniel and Seshadri, Sudha and Saleheen, Danish and Rosand, Jonathan and Markus, Hugh S. and Worrall, Bradford B. and Dichgans, Martin (2016) Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology, 86 (13). pp. 1217-1226. ISSN: 0028-3878

Malik, Rainer and Traylor, Matthew and Pulit, Sara L. and Bevan, Steve and Hopewell, Jemma C. and Holliday, Elizabeth G. and Zhao, Wei and Abrantes, Patricia and Amouyel, Philippe and Attia, John R. and Battey, Thomas W.K. and Berger, Klaus and Boncoraglio, Giorgio B. and Chauhan, Ganesh and Cheng, Yu-Ching and Chen, Wei-Min and Clarke, Robert and Cotlarciuc, Ioana and Debette, Stephanie and Falcone, Guido J. and Ferro, Jose M. and Gamble, Dale M. and Ilinca, Andreea and Kittner, Steven J. and Kourkoulis, Christina E. and Lemmens, Robin and Levi, Christopher R. and Lichtner, Peter and Lindgren, Arne and Liu, Jingmin and Meschia, James F. and Mitchell, Braxton D. and Oliveira, Sofia A. and Pera, Joana and Reiner, Alex P. and Rothwell, Peter M. and Sharma, Pankaj and Slowik, Agnieszka and Sudlow, Cathie L.M. and Tatlisumak, Turgut and Thijs, Vincent and Vicente, Astrid M. and Woo, Daniel and Seshadri, Sudha and Saleheen, Danish and Rosand, Jonathan and Markus, Hugh S. and Worrall, Bradford B. and Dichgans, Martin (2016) Low-frequency and common genetic variation in ischemic stroke. Neurology, 86 (13). pp. 1217-1226. ISSN: 0028-3878

Seppälä, Ilkka and Kleber, Marcus E. and Bevan, Stephen and Lyytikäinen, Leo-Pekka and Oksala, Niku and Hernesniemi, Jussi A. and Mäkelä, Kari-Matti and Rothwell, Peter M. and Sudlow, Cathie and Dichgans, Martin and Mononen, Nina and Vlachopoulou, Efthymia and Sinisalo, Juha and Delgado, Graciela E. and Laaksonen, Reijo and Koskinen, Tuomas and Scharnagl, Hubert and Kähönen, Mika and Markus, Hugh S. and März, Winfried and Lehtimäki, Terho (2016) Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Scientific Reports, 6 (1). ISSN: 2045-2322

Seppälä, Ilkka and Kleber, Marcus E. and Bevan, Steve and Lyytikäinen, Leo-Pekka and Oksala, Niku and Hernesniemi, Jussi A. and Mäkelä, Kari-Matti and Rothwell, Peter M. and Sudlow, Cathie and Dichgans, Martin and Mononen, Nina and Vlachopoulou, Efthymia and Sinisalo, Juha and Delgado, Graciela E. and Laaksonen, Reijo and Koskinen, Tuomas and Scharnagl, Hubert and Kähönen, Mika and Markus, Hugh S. and März, Winfried and Lehtimäki, Terho (2016) Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Scientific Reports, 6. pp. 23207. ISSN: 2045-2322

Rutten-Jacobs, Loes C. A. and Traylor, Matthew and Adib-Samii, Poneh and Thijs, Vincent and Sudlow, Cathie and Rothwell, Peter M. and Boncoraglio, Giorgio and Dichgans, Martin and Meschia, James and Maguire, Jane and Levi, Christopher and Rost, Natalia S. and Rosand, Jonathan and Hassan, Ahamad and Bevan, Steve and Markus, Hugh S. (2016) Association of MTHFR C677T genotype with ischemic stroke is confined to cerebral small vessel disease subtype. Stroke: a Journal of Cerebral Circulation, 47 (3). pp. 646-651. ISSN: 0039-2499

Rutten-Jacobs, Loes C. A. and Traylor, Matthew and Adib-Samii, Poneh and Thijs, Vincent and Sudlow, Cathie and Rothwell, Peter M. and Boncoraglio, Giorgio and Dichgans, Martin and Meschia, James and Maguire, Jane and Levi, Christopher and Rost, Natalia S. and Rosand, Jonathan and Hassan, Ahamad and Bevan, Steve and Markus, Hugh S. (2016) Association of MTHFRC677T genotype With ischemic stroke Is confined to cerebral small vessel disease subtype. Stroke. pp. STROKEAHA.115.011545. ISSN: 0039-2499

Harris, Sarah E. and Malik, Rainer and Marioni, Riccardo and Campbell, Archie and Seshadri, Sudha and Worrall, Bradford B. and Sudlow, Cathie L. M. and Hayward, Caroline and Bastin, Mark E. and Starr, John M. and Porteous, David J. and Wardlaw, Joanna M. and Deary, Ian J. and METASTROKE Consortium, . (2016) Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86 (7). pp. 611-618. ISSN: 0028-3878

Cheng, Yu-Ching and Stanne, Tara M. and Giese, Anne-Katrin and Ho, Weang Kee and Traylor, Matthew and Amouyel, Philippe and Holliday, Elizabeth G. and Malik, Rainer and Xu, Huichun and Kittner, Steven J. and Cole, John W. and O'Connell, Jeffrey R. and Danesh, John and Rasheed, Asif and Zhao, Wei and Engelter, Stefan and Grond-Ginsbach, Caspar and Kamatani, Yoichiro and Lathrop, Mark and Leys, Didier and Thijs, Vincent and Metso, Tiina M and Tatlisumak, Turgut and Pezzini, Alessandro and Parati, Eugenio A and Norrving, Bo and Bevan, Steve and Rothwell, Peter M. and Sudlow, Cathie and Slowik, Agnieszka and Lindgren, Arne and Walters, Matthew R. and Jannes, Jim and Shen, Jess and Crosslin, David and Doheny, Kimberly and Laurie, Cathy C. and Kanse, Sandip M. and Bis, Joshua C. and Fornage, Myriam and Mosley, Thomas H. and Hopewell, Jemma C. and Strauch, Konstantin and Müller-Nurasyid, Martina and Gieger, Christian and Waldenberger, Melanie and Peters, Annette and Meisinger, Christine and Ikram, M Arfan and Longstreth, W. T. and Meschia, James F. and Seshadri, Sudha and Sharma, Pankaj and Worrall, Bradford and Jern, Christina and Levi, Christopher and Dichgans, Martin and Boncoraglio, Giorgio B. and Markus, Hugh S. and Debette, Stephanie and Rolfs, Arndt and Saleheen, Danish and Mitchell, Braxton D. (2016) Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2. Stroke: a Journal of Cerebral Circulation, 47 (2). pp. 307-16. ISSN: 0039-2499

Harris, Sarah E. and Malik, Rainer and Marioni, Riccardo and Campbell, Archie and Seshadri, Sudha and Worrall, Bradford B. and Sudlow, Cathie L.M. and Hayward, Caroline and Bastin, Mark E. and Starr, John M. and Porteous, David J. and Wardlaw, Joanna M. and Deary, Ian J. and , (2016) Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86 (7). pp. 611-618. ISSN: 0028-3878

Traylor, Matthew and Anderson, Christopher D. and Hurford, Robert and Bevan, Steve and Markus, Hugh S. (2016) Oxidative phosphorylation and lacunar stroke. Neurology, 86 (2). pp. 141-145. ISSN: 0028-3878

Traylor, Matthew and Anderson, Christopher D. and Hurford, Robert and Bevan, Steve and Markus, Hugh S. (2016) Oxidative phosphorylation and lacunar stroke: genome-wide enrichment analysis of common variants. Neurology, 86 (2). pp. 141-145. ISSN: 0028-3878

Traylor, Matthew and Zhang, Cathy R. and Adib-Samii, Poneh and Devan, William J. and Parsons, Owen E. and Lanfranconi, Silvia and Gregory, Sarah and Cloonan, Lisa and Falcone, Guido J. and Radmanesh, Farid and Fitzpatrick, Kaitlin and Kanakis, Allison and Barrick, Thomas R. and Moynihan, Barry and Lewis, Cathryn M. and Boncoraglio, Giorgio B. and Lemmens, Robin and Thijs, Vincent and Sudlow, Cathie and Wardlaw, Joanna and Rothwell, Peter M. and Meschia, James F. and Worrall, Bradford B. and Levi, Christopher and Bevan, Steve and Furie, Karen L. and Dichgans, Martin and Rosand, Jonathan and Markus, Hugh S. and Rost, Natalia (2016) Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology, 86 (2). pp. 146-153. ISSN: 0028-3878

Traylor, Matthew and Zhang, Cathy R. and Adib-Samii, Poneh and Devan, William J. and Parsons, Owen E. and Lanfranconi, Silvia and Gregory, Sarah and Cloonan, Lisa and Falcone, Guido J. and Radmanesh, Farid and Fitzpatrick, Kaitlin and Kanakis, Allison and Barrick, Thomas R. and Moynihan, Barry and Lewis, Cathryn M. and Boncoraglio, Giorgio B. and Lemmens, Robin and Thijs, Vincent and Sudlow, Cathie and Wardlaw, Joanna and Rothwell, Peter M. and Meschia, James F. and Worrall, Bradford B. and Levi, Christopher and Bevan, Steve and Furie, Karen L. and Dichgans, Martin and Rosand, Jonathan and Markus, Hugh S. and Rost, Natalia (2016) Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology, 86 (2). pp. 146-153. ISSN: 0028-3878

Gesierich, Benno and Opherk, Christian and Rosand, Jonathan and Gonik, Mariya and Malik, Rainer and Jouvent, Eric and Hervé, Dominique and Adib-Samii, Poneh and Bevan, Steve and Pianese, Luigi and Silvestri, Serena and Dotti, Maria T. and De Stefano, Nicola and van der Grond, Jeroen and Boon, Elles M. J. and Pescini, Francesca and Rost, Natalia and Pantoni, Leonardo and Lesnik Oberstein, Saskia A. and Federico, Antonio and Ragno, Michele and Markus, Hugh S. and Tournier-Lasserve, Elisabeth and Chabriat, Hugues and Dichgans, Martin and Duering, Marco and Ewers, Michael (2016) APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL. Journal of Cerebral Blood Flow & Metabolism. ISSN: 0271-678X

Hanscombe, Ken B. and Traylor, Matthew and Hysi, Pirro G. and Bevan, Stephen and Dichgans, Martin and Rothwell, Peter M. and Worrall, Bradford B. and Seshadri, Sudha and Sudlow, Cathie and Williams, Frances M. K. and Markus, Hugh S. and Lewis, Cathryn M. (2015) Genetic factors influencing coagulation factor XIII B-subunit contribute to risk of ischemic stroke. Stroke, 46 (8). pp. 2069-2074. ISSN: 0039-2499

Rutten-Jacobs, Loes C.A. and Traylor, Matthew and Adib-Samii, Poneh and Thijs, Vincent and Sudlow, Cathie and Rothwell, Peter M. and Boncoraglio, Giorgio and Dichgans, Martin and Bevan, Steve and Meschia, James and Levi, Christopher and Rost, Natalia S. and Rosand, Jonathan and Hassan, Ahamad and Markus, Hugh S. (2015) Common NOTCH3 variants and cerebral small-vessel disease. Stroke, 46 (6). pp. 1482-1487. ISSN: 0039-2499

Traylor, Matthew and Rutten-Jacobs, Loes C. A. and Holliday, Elizabeth G. and Malik, Rainer and Sudlow, Cathie and Rothwell, Peter M. and Maguire, Jane M. and Koblar, Simon A. and Bevan, Steve and Boncoraglio, Giorgio and Dichgans, Martin and Levi, Chris and Lewis, Cathryn M. and Markus, Hugh S. (2015) Differences in common genetic predisposition to ischemic stroke by age and sex. Stroke: a journal of cerebral circulation, 46 (11). pp. 3042-7. ISSN: 0039-2499

Traylor, Matthew and Bevan, Stephen and Baron, Jean-Claude and Hassan, Ahamad and Lewis, Cathryn M. and Markus, Hugh S. (2015) Genetic architecture of lacunar stroke. Stroke; a journal of cerebral circulation, 46 (9). pp. 2407-2412. ISSN: 0039-2499

Kilarski, Laura L. and Rutten-Jacobs, Loes C. A. and Bevan, Stephen and Baker, Rob and Hassan, Ahamad and Hughes, Derralynn A. and Markus, Hugh S. (2015) Prevalence of CADASIL and Fabry disease in a cohort of MRI defined younger onset lacunar stroke. PloS one, 10 (8). pp. e0136352. ISSN: 1932-6203

Rannikmae, K. and Davies, G. and Thomson, P. A. and Bevan, S. and Devan, W. J. and Falcone, G. J. and Traylor, M. and Anderson, C. D. and Battey, T. W. K. and Radmanesh, F. and Deka, R. and Woo, J. G. and Martin, L. J. and Jimenez-Conde, J. and Selim, M. and Brown, D. L. and Silliman, S. L. and Kidwell, C. S. and Montaner, J. and Langefeld, C. D. and Slowik, A. and Hansen, B. M. and Lindgren, A. G. and Meschia, J. F. and Fornage, M. and Bis, J. C. and Debette, S. and Ikram, M. A. and Longstreth, W. T. and Schmidt, R. and Zhang, C. R. and Yang, Q. and Sharma, P. and Kittner, S. J. and Mitchell, B. D. and Holliday, E. G. and Levi, C. R. and Attia, J. and Rothwell, P. M. and Poole, D. L. and Boncoraglio, G. B. and Psaty, B. M. and Malik, R. and Rost, N. and Worrall, B. B. and Dichgans, M. and Van Agtmael, T. and Woo, D. and Markus, H. S. and Seshadri, S. and Rosand, J. and Sudlow, C. L. M. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84 (9). pp. 918-926. ISSN: 0028-3878

Adib-Samii, Poneh and Devan, William and Traylor, Matthew and Lanfranconi, Silvia and Zhang, Cathy R. and Cloonan, Lisa and Falcone, Guido J. and Radmanesh, Farid and Fitzpatrick, Kaitlin and Kanakis, Allison and Rothwell, Peter M. and Sudlow, Cathie and Boncoraglio, Giorgio B. and Meschia, James F. and Levi, Chris and Dichgans, Martin and Bevan, Steve and Rosand, Jonathan and Rost, Natalia S. and Markus, Hugh S. (2015) Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. Stroke, 46 (2). pp. 348-353. ISSN: 0039-2499

Holliday, Elizabeth G. and Traylor, Matthew and Malik, Rainer and Bevan, Stephen and Maguire, Jane and Koblar, Simon A. and Sturm, Jonathan and Hankey, Graeme J. and Oldmeadow, Christopher and McEvoy, Mark and Sudlow, Cathie and Rothwell, Peter M. and Coresh, Josef and Hamet, Pavel and Tremblay, Johanne and Turner, Stephen T. and de Andrade, Mariza and Rao, Madhumathi and Schmidt, Reinhold and Crick, Peter A. and Robino, Antonietta and Peralta, Carmen A. and Jukema, J. Wouter and Mitchell, Paul and Rosas, Sylvia E. and Wang, Jie Jin and Scott, Rodney J. and Dichgans, Martin and Mitchell, Braxton D. and Kao, W.H. Linda and Fox, Caroline S. and Levi, Christopher and Attia, John and Markus, Hugh S. (2014) Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke, 45 (12). pp. 3508-3513. ISSN: 0039-2499

Markus, Hugh S. and Bevan, Steve (2014) Mechanisms and treatment of ischaemic stroke: insights from genetic associations. Nature Reviews Neurology, 10 (12). pp. 723-730. ISSN: 1759-4758

Kilarski, L. L. and Achterberg, S. and Devan, W. J. and Traylor, M. and Malik, R. and Lindgren, A. and Pare, G. and Sharma, P. and Slowik, A. and Thijs, V. and Walters, M. and Worrall, B. B. and Sale, M. M. and Algra, A. and Kappelle, L. J. and Wijmenga, C. and Norrving, B. and Sandling, J. K. and Ronnblom, L. and Goris, A. and Franke, A. and Sudlow, C. and Rothwell, P. M. and Levi, C. and Holliday, E. G. and Fornage, M. and Psaty, B. and Gretarsdottir, S. and Thorsteinsdottir, U. and Seshadri, S. and Mitchell, B. D. and Kittner, S. and Clarke, R. and Hopewell, J. C. and Bis, J. C. and Boncoraglio, G. B. and Meschia, J. and Ikram, M. A. and Hansen, B. M. and Montaner, J. and Thorleifsson, G. and Stefanson, K. and Rosand, J. and de Bakker, P. I. W. and Farrall, M. and Dichgans, M. and Markus, H. S. and Bevan, S. (2014) Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, 83 (8). pp. 678-685. ISSN: 0028-3878

Frayling, Timothy M. and Traylor, Matthew and Mäkelä, Kari-Matti and Kilarski, Laura L. and Holliday, Elizabeth G. and Devan, William J. and Nalls, Mike A. and Wiggins, Kerri L. and Zhao, Wei and Cheng, Yu-Ching and Achterberg, Sefanja and Malik, Rainer and Sudlow, Cathie and Bevan, Steve and Raitoharju, Emma and Oksala, Niku and Thijs, Vincent and Lemmens, Robin and Lindgren, Arne and Slowik, Agnieszka and Maguire, Jane M. and Walters, Matthew and Algra, Ale and Sharma, Pankaj and Attia, John R. and Boncoraglio, Giorgio B. and Rothwell, Peter M. and de Bakker, Paul I. W. and Bis, Joshua C. and Saleheen, Danish and Kittner, Steven J. and Mitchell, Braxton D. and Rosand, Jonathan and Meschia, James F. and Levi, Christopher and Dichgans, Martin and Lehtimäki, Terho and Lewis, Cathryn M. and Markus, Hugh S. (2014) A novel MMP12 locus Is associated with large artery atherosclerotic stroke Using a genome-wide age-at-onset informed approach. PLoS Genetics, 10 (7). pp. e1004469. ISSN: 1553-7390

Opherk, C. and Gonik, M. and Duering, M. and Malik, R. and Jouvent, E. and Herve, D. and Adib-Samii, P. and Bevan, S. and Pianese, L. and Silvestri, S. and Dotti, M. T. and De Stefano, N. and Liem, M. and Boon, E. M. J. and Pescini, F. and Pachai, C. and Bracoud, L. and Muller-Myhsok, B. and Meitinger, T. and Rost, N. and Pantoni, L. and Lesnik Oberstein, S. and Federico, A. and Ragno, M. and Markus, H. S. and Tournier-Lasserve, E. and Rosand, J. and Chabriat, H. and Dichgans, M. (2014) Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL. Stroke, 45 (4). pp. 968-972. ISSN: 0039-2499

Thapaliya, Arjun and Nyathi, Yvonne and Martínez-Lumbreras, Santiago and Krysztofinska, Ewelina M. and Evans, Nicola J. and Terry, Isabelle L. and High, Stephen and Isaacson, Rivka L. (2016) SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism. Scientific Reports, 6 (1). pp. 36622. ISSN: 2045-2322

Leznicki, P. and Korac-Prlic, J. and Kliza, K. and Husnjak, K. and Nyathi, Y. and Dikic, I. and High, S. (2015) Binding of SGTA to Rpn13 selectively modulates protein quality control. Journal of Cell Science, 128 (17). pp. 3187-3196. ISSN: 0021-9533

Nyathi, Yvonne and Pool, Martin R. (2015) Analysis of the interplay of protein biogenesis factors at the ribosome exit site reveals new role for NAC. Journal of Cell Biology, 210 (2). pp. 287-301. ISSN: 0021-9525

Yamashita, M. and Shepherd, M. and Booth, W. I. and Xie, H. and Postis, V. and Nyathi, Y. and Tzokov, S. B. and Poole, R. K. and Baldwin, S. A. and Bullough, P. A. (2014) Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. Journal of Biological Chemistry, 289 (33). pp. 23177-23188. ISSN: 0021-9258

Applications from prospective MSc by Research (MScRes), MPhil or PhD students to join our research laboratories are always welcome. Funded positions, as they arise, are advertised via the University of Lincoln Job Opportunities webpage and relevant national advertising portals. In addition, we do consider applicants for postgraduate studies in our relevant research areas, who are able to fund their studies themselves or from independent sources. Funding for postgraduate studies should normally include tuition fees, stipend and costs to cover consumables and bench fees. For further information and list of relevant topics, please refer to pages of our individual laboratories and potential supervisors.

Current and recent postgraduate research students:

  • Tammy Wiltshire - RECQL4; linking DNA replication to bone tumourigenesis - Csanad Bachrati, Timea Palmai-Pallag
  • Irene Boateng - Prof Carlos Rodriguez Pascual
  • Joshua Kaye - Establishing a link between Mesenchymal Stem Cell differentiation and the development of Osteosarcoma - Csanad Bachrati, Timea Palmai-Pallag
  • Lisa Chacko - Linking DNA replication to bone tumourigenesis - Csanad Bachrati, Timea Palmai-Pallag
  • James Lally
    • Supervisor – Carol Rea / Ciaren Graham / Ciro Rinaldi
    • Title - Role of JAK2 in myeloproliferative neoplasms
  • Rachel Simpson
    • Supervisor – Ciro Rinaldi / Matt Simmonds / Carol Rea
  • Joseph Brightmore
    • Supervisors – Stefan Milson / Paul Squires / Ed Taylor
    • Title – A proteomic study on the molecular switch controlling Heat Shock Protein 90, and possible target as a multi-drug cancer therapy.
  • Kristian Boasman
    • Supervisors – Matt Simmonds / Ciro Rinaldi / Chris Bridle
    • Title – Elucidating the molecular mechanisms of calreticulin and CD47 in MDS and MPN
  • Alex Lupton
    • Supervisors – Issam Hussain
    • Title – Anticancer effects of hydrogen sulphide donor molecules

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School of Life Sciences, University of Lincoln, Brayford Pool, Lincoln. LN6 7TS 

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